Generally, it’s given at a starting dose of 7.5mg mirtazapine, to be taken at bedtime. It’s worth noting that the sedative effects of mirtazapine are thought to be greater at low dose and are lost at higher dose. If you are prescribed mirtazapine for sleep problems, it’s usually given at a low dosage. If found necessary, 45mg mirtazapine can be given as a single dose per day or split into two doses during the day.
After this time, the dose may be adjusted to suit how your body is responding to it. When mirtazapine is prescribed to treat depression or anxiety, it’s initially recommended at a dose of 15–30 mg per day, taken at bedtime, for two to four weeks. It’s also available in a liquid form, at a dose of 15mg per ml. Mirtazapine is available as 15mg, 30mg and 45mg doses, in both standard tablet form and dispersible tablet form. Weight gain is also considered a common side-effect of mirtazapine, with one study on healthy males concluding that the drug may change the user’s metabolism slightly and increase cravings for sweet foods. It may also increase the occurrence of restless legs syndrome and periodic limb movements 4 both of which can significantly disrupt your sleep. It can also leave some people feeling groggy or feeling like they have a slight hangover, so following the prescribed dosage is very important. While mirtazapine may help you to sleep better while you’re taking it, it’s well recognised that insomnia can develop after stopping taking the drug.ĭue to its sedating effects, mirtazapine can lead to daytime drowsiness. It’s interesting to note that mirtazapine may cause ‘sleep disorders’, with fatigue also being a common side effect. diarrhoea, nausea, constipation and vomiting.dry mouth, joint pain, muscle aches and pains.increased appetite, water retention and weight gain.Side effects are not uncommon when taking mirtazapine and can include: It’s not clear whether it’s the drug itself which reduces the symptoms of insomnia or whether, by reducing the severity of depressive symptoms, it has the knock-on effect of helping the person to sleep better. There’s some evidence that mirtazapine can be an effective treatment for insomnia in people with depression. Mirtazapine doesn’t stop the recycling of these messengers but instead blocks some of the receptors they interact with. Mirtazapine, like many other antidepressants, works by increasing the concentration of certain neurotransmitters (chemical messengers) in the brain but differs to many others on the market in just how it does that. Mirtazapine is still branded as Remeron in most countries but, as it’s no longer patented, generic versions are sold under various brand names around the world. It was launched in the United States in 1996 under the brand name Remeron. Mirtazapine was developed by the Dutch pharmaceutical company Organon and was first approved for its use in major depressive disorder in the Netherlands in 1994. It’s also known by the brand name Remeron in the USA. In the UK, mirtazapine is licensed for the treatment of major depression, obsessive compulsive disorder and anxiety. One of the drugs commonly used in this way is mirtazapine. These drugs are used ‘off label’ meaning that they are given for a condition for which they are not licensed, in order to try and treat insomnia. So, instead, GPs tend to opt for using other drugs which have sedative side-effects. Many doctors are reluctant to prescribe sleeping tablets because of concerns that they can lead to problems with addiction and tolerance.
Treating insomnia with medication can be a fine balancing act. are there better solutions to fix a sleep problem?.
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